Exosomes for DMD

, Dmd

Prosthodontics, Scranton, Pennsylvania. ter of routine. However, in anterior implant -supported restorations, the successful achievement of the aesthetic goal can often be elusive. The task is made especially arduous when the potential implant recipient site lies within the lip perimeter and is compromised by significant hard and soft tissue defects and/or inharmonious occlusal combinations. Un...

Exon skipping for DMD

Duchenne muscular dystrophy (DMD) is a severe, progressive muscle-wasting disorder, while Becker muscular dystrophy (BMD) is milder muscle disease [1]. Both are caused by mutations in dystrophin, a protein, which stabilizes muscle fibers during contraction by linking muscle actin to the extracellular matrix. In DMD patients mutations disrupt the open reading frame, generating prematurely trunca...

Exosomes for cancer immunotherapy.

Exosomes are small vesicles originating from late endosomes and are released in the extracellular medium by a broad array of cells. They were initially described by Johnstone et al. [1] in reticulocytes where multi-vesicular bodies (MVBs) fused with the plasma membrane in an exocytic manner. This exosome secretion was later shown to occur in a wide variety of cell types, including B lymphocytes...

DMD # 10249 1 Enzyme

Engineering Exosomes for Cancer Therapy

There remains an urgent need for novel therapeutic strategies to treat metastatic cancer, which results in over 8 million deaths annually worldwide. Following secretion, exosomes are naturally taken up by cells, and capable of the stable transfer of drugs, therapeutic microRNAs and proteins. As knowledge of the biogenesis, release and uptake of exosomes continues to evolve, and thus also has in...